Ute Kothe (University of Manitoba, Canada), Jane Jackman (The Ohio State University, USA) and Sebastian Leidel (University of Bern) together with Journal of Molecular Biology are organizing a special issue focused on the “tRNA modifications”.
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tRNA modifications are back in the spotlight of current research. Long known and sometimes underappreciated, they make tRNA the most chemically diverse of all cellular RNAs. We are now witnessing exciting new developments in the understanding of the regulation and biological functions of various tRNA-modifying enzymes and their products. With the advent of epitranscriptomics and the discovery of mRNA modifications, new detection technologies for RNA modifications have been established and are now similarly accelerating the field of tRNA modification in combination with structural, biochemical, cellular, and organismal studies. Today, tRNA modifications are known to affect cellular fate in response to stress and disease states.
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In this special issue through a collection of research and review articles we will highlight the latest developments towards a comprehensive understanding of tRNA modification biology. By featuring complementary approaches to the study of tRNA modifications, readers will gain an informative overview of the mechanisms, functions, and regulations of various tRNA modifications in protein synthesis and beyond. In addition, readers will learn about the latest experimental approaches to advance our knowledge of tRNA modifications.
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The editors would like to invite researchers working in this field to submit Research Articles to join this special collection. The submission date is 15 November 2024.
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The research article should be in line with JMB’s scope: a molecular mechanistic study having a biological or disease relevance and contributing to the understanding of a significant biological or biochemical mechanism. The work should be of interest to a broad biologically oriented readership of JMB.
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Please let us know if you think you might have a suitable paper.