Biased signaling, or functional selectivity, in receptors, especially in G protein-coupled receptors, has received significant interest recently in studies on receptor pharmacology and drug development, aimed towards developing new drugs with better therapeutic efficacy and less side effects. Ligands working on a receptor can preferentially activate one signaling pathway over another. In addition to biased ligands, mutated receptors can also be biased. This virtual issue presents a survey of current status of biased signaling in a selected subset of receptors, primarily in G protein-coupled receptors.
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Guest editors:
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Ya-Xiong Y.X. Tao - Auburn University, Auburn, Alabama, USA
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Alfredo A. Ulloa-Aguirre - UNAM, Mexico City, Mexico