Endocrine and endocrine-related functions of-or-in the intestinal pathophysiology: what comes first?
摘要截稿:
全文截稿: 2024-07-31
影响因子: 3.871
期刊难度:
CCF分类: 无
中科院JCR分区:
• 大类 : 医学 - 2区
• 小类 : 细胞生物学 - 3区
• 小类 : 内分泌学与代谢 - 3区
Overview
Enlarge our knowledge on how hormones impact intestinal pathophysiology with consequences on human health.Guest editors:
Michelina Plateroti,Institute of Genetics and Molecular and Cellular Biology, Université de Strasbourg, FranceEmail: plateroti@unistra.fr
Maria Sirakov,Department of Biology and Evolution of Marine Organisms,Stazione Zoologica Anton Dohrn, Naples, ItalyEmail: maria.sirakov@szn.it
Special issue information:
The intestine is a complex organ organized along the proximo-distal axis, playing multiple and regionalized functions. This includes absorption of nutriments and water, barrier against the external environment (luminal content), protection against infections (innate or acquired immunity). It is considered, together with liver and skeletal muscles, one important metabolic organ that also is a source of hormones and hormone-binding proteins.
Interestingly, despite the functional differences in each region of the intestine, the epithelium is organized in a vertical axis, with stem cells located at the very bottom of the axis. These cells are very active and regenerate the entire epithelium in a few days. Given this high proliferation rate, this tissue undergoes cancer development very frequently. In addition, inflammatory bowel diseases (IBD) are pathologies which compromise epithelial regeneration, barrier and function. Unfortunately, colorectal cancers and IBDs are increasing in western and westernized countries, becoming a great concern of public health. Recently, several reports also underlined the pivotal role of the of Gut-Brain-axis involved in neurological diseases.
The aim of this special issue is to gather together review articles summarizing how intestine-produced hormones and/or hormone binding proteins, including but not limited to nuclear hormone receptors, influence general physiology and metabolism and, viceversa, how hormones impact intestinal pathophysiology with consequences on human health.