Supercritical fluid chromatography and related techniques
摘要截稿:
全文截稿: 2024-09-30
影响因子: 4.049
期刊难度:
CCF分类: 无
中科院JCR分区:
• 大类 : 化学 - 2区
• 小类 : 生化研究方法 - 1区
• 小类 : 分析化学 - 2区
Overview
Journal of Chromatography A will be launching a Virtual Special Issue (VSI) in March 2024 entitled "Supercritical fluid chromatography and related techniques".
Guest editors:
Professor Marja-Liisa RiekkolaEmail: marja-liisa.riekkola@helsinki.fiAffiliation: University of Helsinki, Helsinki, Finland
Professor Caroline WestEmail: caroline.west@univ-orleans.frAffiliation: Université d'Orléans, UMR CNRS, Orleans, France
Professor Torgny Fornstedt Email: torgny.fornstedt@kau.seAffiliation: Karlstad University, Fundamental Separation Science Group, Karlstad, Sweden
Special issue information:
Initially SFC using capillary columns gained popularity in the 1990s for both achiral and chiral separations. Then thanks to the introduction of packed columns and the addition of co-solvents, it quickly became a preferred method for isolating optical isomers of drugs during the discovery phase, being faster and eco-friendlier than preparative LC. However, the compressibility of the eluent rendered SFC less stable compared to LC, leading to a lack of fundamental understanding. Efforts over the past few decades, through academic and industrial collaboration, have addressed this issue, resulting in more reliable scaling up and improved analytical and preparative instrumentation.
More recently, SFC has again drawn the attention of chromatographers. This resurgence is due to diversification in related techniques and addressing new separation challenges that remained unsolved with existing techniques or by seeking complementary separation methods. While carbon dioxide may still be the primary fluid used, the exact state of the fluid is not necessarily supercritical anymore. As a result, studies carried out with “SFC instruments” today might use subcritical fluids, or so-called “enhanced-fluidity liquids” when the proportion of pressurized CO2 is low compared to the organic co-solvent. Another recent evolution is the integration of wide elution gradients, starting in supercritical conditions and ending in liquid conditions.
Altogether, the fundamental issues, as well as the new, more esoteric techniques related to SFC, require a wide range of academic and industrial expertise, whether studying fundamental issues or introducing new applications – analytical, preparative, chiral, or achiral.
In this special issue, we hope to show the diversity of questions and challenges addressed by SFC and related techniques.
Manuscript submission information:
This special issue is Guest Editor Invitation Only.
Submission open date: 15 March 2024
Submission deadline: 30 September 2024